NORMAL PHYSIOLOGICAL VALUES FOR HANFORD MINIATURE SWINE
The miniature swine have been increasingly recognized as a non-rodent model in regulatory toxicity. Members of the FDA have even published on the use of miniature swine as an alternative to canine and non-human primates in regulatory toxicity. The similarities between the cardiovascular, renal, and digestive systems make the miniature swine a suitable animal to model the human counterpart. The miniature swine are also the most recognized species for dermal toxicology. The Hanford miniature swine (HMS) has other attractive traits that make them a good substitute to model humans. They are omnivorous, easy to handle, prone to obesity, and will develop atherosclerosis and dyslipidemia if fed a high fat diet. With the advent of new techniques, all routes of compound administration can be used with miniature swine. The HMS should be considered as one of the non-rodent species in toxicity testing. In an effort to generate a database on baseline information about the normal physiological status of the Hanford miniature swine, we report physiological data from normal intact and naïve juvenile and young adult miniature swine of both genders. The normal physiological data gathered includes growth parameters, hematology, serum chemistry, coagulation profile, urinalysis, ECG rhythm and segment intervals, and organ weights.
Ross, M., Brown, L., Unterreiner, D., Hanks, C., Liu, J., Hiemstra, J., Bouchard, G.F.