Porcine Integumentary System Models: Dermal Toxicology
Swine have been used extensively in dermal research because of the similarities to humans. In the field of toxicology the skin has been used for acute and repeat dose dermal toxicology, dermal absorption, phototoxicity, allergic contact dermatitis and photosensitisation studies. Both miniature and domestic breeds have been used for these types of studies, however, miniature breeds may be more advantageous because of their size at sexual maturity. The Sinclair, Yucatan and Hanford minipigs may all be utilized in some aspect of dermal toxicology. Using them allows the investigator to conduct experiments in mature rather than pediatric animals with a consistent size and health status as compared to farm pigs. Models are done both in vivo as well as in vitro with skin membranes and grafts. Reviews of the use of swine in these studies have been published.Information on porcine models involving the integumentary system will be published on this website in two parts. The first part will summarize models related to dermal toxicology and the second part will discuss skin closure and wound healing models.
M. Michael Swindle, DVM, Professor and Chairman, Department of Comparative Medicine, Medical University of SC, Charleston, SC 29425